Are you asking for a daily task or a one time solution?
@bikermanirl Yes of course through script you can manage this stuff. btw do you already have list of sku's ? Or that also need to figure out ?
Maybe you can try to run this into your database:
DELETE FROM catalog_product_entity WHERE sku in (sku1, sku2, sku3, sku4, ...);
Please, rememeber to make a database backup before execute the scrtipt.
Also, after the scritp has finished you should reindex (use the bin/magento indexer:reindex)