We have our website set to round off prices in the order's which works perfectly fien when a custoemr places an order but the issue is when we create an order from the backend the rounding dissapears, is it possible to set magento up so that the prices will stay rounded when we create or edit a order directly fromt he backend?
Yes it is possible. You need to check this extension out : http://www.magentocommerce.com/magento-connect/et-currency-manager.html
We do have that extension installed and are currently using it.
What settings do you suggest we modify to be able to do as needed?
In Extension Configuration -> Currency option section
1. "Enable for Admin" set to yes
2. Precision set to 4
Ok, in this case you need to debug the code for the issue and make changes according to.