Your question is pretty wide, can you pleae elaborate?
I uploaded CSV file of products and updated the pricing. I need to upload updated CSV files for the same products but don't want the pricing that I set to change.
I do it all the time on v220.127.116.11 - I just use a CSV with the SKU and Price column for the products I want to update.
It updates the products in the list and leaves the others as they are.