Ensure 100% API coverage, clean up current frontend stack and move to more component based approach, try to make easier to use existing frontend tools like Webpack... and much more smaller topics sums to one big one about the general direction of Magento 2 front-end.
It's a continuation of talks started as "LESS to SASS Community project", which goes wild over the time and now cover way more area than just styles.
BTW. It's probably only one clearly front-end oriented topic on board.