This was true for previous versions (most notably 1.4.X and 1.5.X) but considering the advancements in PHP in the last 5 or so years, it is less of a benefit. In fact, when compared to disabling it completely and leveraging APC (now deprecated for the latest PHP versions), OpCache, or Zend's Optimizer+ it can often result in degraded performance. When these are combined with optimizations of realpath_cache_size=64k and realpath_cache_ttl=3600, enabling compilation may wind up doing more harm than good, at least for Magento 1.6.1 and upwards. Every deployment enviornment is, of course, unique but the general consensus is that unless you're running a really old version of Magento (or perhaps Mage....
Pretty much been my experience. A lot of cargo cult Magento experts out there will chant the mantra "enable compiler" but I've found it to be nothing but trouble and all the other methods of speeding your site up will deliver larger gains than the mediocre speed gain of having the compiler enabled and not leave you open to some spectacular site nukes when compilation goes bad. From 1.6 forward, you're better off without it.
I agree with the technical recommendations offered by @chiefair's accepted answer, but I recently answered a couple of similar or at least related questions on the Magento Stack Exchange and thought I would follow up with some of the additional insights from a few more recent remediation efforts.
A security incident like this one is a challenge that must be addressed with responses from both the technical and business perspectives and given that the business implications include potential regulatory and contractual requirements that specifically impact the technical actions you may be required to perform, I thought I would outline them together in this answer.
Before performing any of the earlier recommended technical activities, review the following and determine which, if any, are allowed given the regulations you are subject to in your location and the contracts you have entered into with your issuing banks, gateway providers and processing service partners.
Depending on your location, you may be subject to local, regional, and / or national laws that require you to either perform very specific actions in response to a security event or to engage the assistance of someone (or a company) that is specifically licensed as a forensic information security specialist.
In addition, the fine print of the credit card processing agreements signed with the store's Credit Card Merchant Gateway, Financial Institution, Issuing Bank, and the Credit Companies themselves may require other specific actions be performed and that law enforcement be engaged or the store may be held responsible for any charges incurred by the attacker(s).
Finally, again, depending on your location, your store may be required by law to notify the customers of the data breach in very specific ways and the Nation / States in which your customers reside may impose additional requirements on notifying affected customers. Failure to comply with these requirements might make the store subject liable for fines and penalties outside of any costs imposed by your processing company or gateway provider.
These laws & contractual requirements vary greatly across different geographical regions and also across different financial institution and businesses that offer clearing and gateway services to merchants so it is important to engage the services of someone who is both a Magento Security Expert and also familiar with the laws specific to your geographic location and who can assist you with both the technical effort in remediating your hacked site as well as the business activities required by any contracts that have been entered into by the Merchant.
Once you have identified a suitably experienced partner to assist you in your remediation effort, ask them to confirm the next technical steps to take, including actions such as imaging the compromised system, contacting law enforcement, disconnecting the system from the network and investigating the affected systems.
REMEMBER: You are no longer in possession of JUST a hacked system! Your compromised Magento installation is now also an ACTIVE crime scene, and in many jurisdictions, the crime is a severe one. In the US, it's almost universally a felony (severe crime) with specific prohibitions against tampering with evidence left behind by the perpetuators of the criminal act without proper supervision of licensed personnel and/or law enforcement professionals.
It would be unwise to bring the system back to a working state only to find out that you YOURSELF had just committed a crime punishable by fine and/or jail time. Standard Disclaimer: I am not a lawyer and this does not constitute legal advice.
Note: Most of the links above point to resources specifically written for US Merchants, but they all also contain links for merchants in other regions as well as contact information to engage the specific security support teams to assist you in your own location.