Generally, in Magento the price of associated simple products is being ignored and at the front-end the price of parent configurable products is displayed.
If you want the price to change depending on combinations selected in drop-downs, you can set up price mark-ups in Associated products tab, section Super Product attributes configuration -
Here is also the article for the details -
If I have understood you correctly, you want to change the price of main configurable as well as associated products massively. Basically, if you do not sell your associated products individually (as usually done) you can change just the price of parent configurable and that will be enough.
If you sell associated simple products separately from configurable need to update their prices massively and set the same price for a few goods, you simply can go to Catalog -> Manager Products
There check the boxes for products to update, click Actions - Update Attributes- Submit
and in the line Price set new price for selected products, tick box to update and save changes.
Hope this helps.