I don't know if this works yet since PayPal hasn't added their end (highlighted in bold), but I figured I would share what I know so far:
Thank you for contacting PayPal Merchant Technical Support. I am happy to assist you with the Magento 2.2.2 integration.
Please follow these steps to adjust the settings in your manager account.
1. Login to manager.paypal.com and click Service Settings
2. Select “Set Up”
3. Toggles on this page include:
a. Transaction Process Mode > Live
b. Return URL Method > POST
c. Check CSC boxes under Billing Information for both required and editable fields
d. CSC > No
e. AVS > No
f. Enable Secure Token > Yes
4. Click “Save Changes”
5. Go to Service Settings > Customize
a. Select Layout C > Save and Publish (this avoids a bug that occurs on some accounts for
transparent redirect)
6. Click “Account Administration”
a. Click “Transaction Settings” under Manager Security header
i. Set “Allow Reference Transactions” to “Yes”
Reference transactions need to be enabled on your PayPal account as well, which I have submitted a ticket for. You will receive an email notification when this is complete.
Please let me know if you have further questions or if the issue has been resolved so I can close your support ticket appropriately.
Sincerely,
Alex
Global Technical Support
PayPal, Inc.