We just upgraded to v2.4.3-p1 and have it installed in a subdirectory. We have ALL cron jobs shutoff.
Every so often, the site loses the indexing and is broken. The easy fix is to run bin/magento index:reindex and the site runs perfectly.
Any idea what would cause the indexes to be broken if cron is completely disabled?
There are two ways to run indexing automatically in Magento:
1. Update by schedule (cron base)
2. Update on save (when product/category save/update in admin)
If you aren't able to re-index cron base then you can set indexing mode using "Update on save" from:
Admin -> System -> Index Management