We have the same issue.
Customers can not register in the checkout and are re-directed to the homepage on 188.8.131.52.
But with SUPEE-10570v2 patched over the 184.108.40.206 install it works fine.
Seems that the account register problem on the checkout is not solved in 220.127.116.11.
Will it be save to patch SUPEE-10570v2 over 18.104.22.168?